FUNCTIONAL CORRELATIONS BETWEEN MUCOSAL MAST-CELL ACTIVITY AND IMMUNITY TO TRICHINELLA-SPIRALIS IN HIGH AND LOW RESPONDER MICE

被引：58

作者：

TUOHY, M ^{[1
]}

LAMMAS, DA ^{[1
]}

WAKELIN, D ^{[1
]}

HUNTLEY, JF ^{[1
]}

NEWLANDS, GFJ ^{[1
]}

MILLER, HRP ^{[1
]}

机构：

[1] MOREDUN RES INST,EDINBURGH EH17 7JH,MIDLOTHIAN,SCOTLAND

来源：

PARASITE IMMUNOLOGY | 1990年 / 12卷 / 06期

基金：

英国惠康基金;

关键词：

genetic variation; intestinal mast cell protease; mast cells; Trichinella spiralis;

D O I：

10.1111/j.1365-3024.1990.tb00996.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Summary Levels of intestinal mast cell protease (IMCP) were quantified in serum, gut tissue and in intestinal fluids taken from mice infected with Trichinella spiralis during primary and secondary infections. The ability to generate a mast cell response was dependent on the response phenotype of the mouse strain used. The mast cell response in rapid responder mice (NIH) occurred sooner and was more pronounced than in either intermediate (SWR) and low responder (BIO) mice. This pattern was also reflected in the concentration of IMCP found in various tissues examined. The correlations between IMCP concentrations in blood, and worm expulsion, are discussed. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：675 / 685

页数：11

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