AMOXICILLIN-CLAVULANIC ACID FOR TREATING DRUG-RESISTANT MYCOBACTERIUM-TUBERCULOSIS

被引：94

作者：

NADLER, JP

BERGER, J

NORD, JA

COFSKY, R

SAXENA, M

机构：

[1] UNIV S FLORIDA, SCH MED, DEPT MED, TAMPA, FL 33620 USA

[2] DEPT VET AFFAIRS, BAY PINES, FL USA

来源：

CHEST | 1991年 / 99卷 / 04期

关键词：

D O I：

10.1378/chest.99.4.1025

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic acid, a beta-lactamase inhibitor, and amoxicillin has been shown bactericidal for M tuberculosis in vitro. These data suggest that resistant tuberculosis may warrant a trial of treatment including amoxicillin-clavulanic acid.

引用

页码：1025 / 1026

页数：2

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