POSTNATAL CHANGES IN [H-3] MAZINDOL-LABELED DOPAMINE UPTAKE SITES IN THE RAT STRIATUM FOLLOWING PRENATAL COCAINE EXPOSURE

被引：25

作者：

STADLIN, A ^{[1
]}

CHOI, HL ^{[1
]}

TSANG, D ^{[1
]}

机构：

[1] CHINESE UNIV HONG KONG, DEPT BIOCHEM, SHA TIN, HONG KONG

来源：

BRAIN RESEARCH | 1994年 / 637卷 / 1-2期

关键词：

COCAINE; PRENATAL; H-3] MAZINDOL; DOPAMINE UPTAKE SITE; STRIATUM; POSTNATAL; RAT;

D O I：

10.1016/0006-8993(94)91259-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study showed that prenatal cocaine exposure (60 mg/ kg/ day) has a transient effect on the [H-3]mazindol-labelled dopamine uptake sites in the striatum of the rat offspring examined from postnatal week 0-32. There is a 39% and 21% decrease in the number of binding sites (B-max) in the cocaine-exposed group at postnatal weeks 3 and 4, respectively, with a recovery to near normal values by postnatal week 8.

引用

页码：345 / 348

页数：4

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