LINKER HISTONES H1 AND H5 PREVENT THE MOBILITY OF POSITIONED NUCLEOSOMES

被引：145

作者：

PENNINGS, S

MEERSSEMAN, G

BRADBURY, EM

机构：

[1] UNIV CALIF DAVIS, SCH MED, DEPT BIOL CHEM, DAVIS, CA 95616 USA

[2] LOS ALAMOS NATL LAB, DIV LIFE SCI, LOS ALAMOS, NM 87545 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 22期

关键词：

D O I：

10.1073/pnas.91.22.10275

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is the more potent inhibitor of nucleosome mobility, in accordance with its higher affinity for chromatin, We propose that this reversible restraint on chromatin dynamics may play a role in local regulation of processes that require access to the DNA.

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页码：10275 / 10279

页数：5

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