CORTISOL INDUCTION OF GROWTH HORMONE SYNTHESIS IN A CLONAL LINE OF RAT PITUITARY TUMOR CELLS IN CULTURE

被引：52

作者：

KOHLER, PO

FROHMAN, LA

BRIDSON, WE

VANHAPER.T

HAMMOND, JM

机构：

来源：

SCIENCE | 1969年 / 166卷 / 3905期

关键词：

D O I：

10.1126/science.166.3905.633

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH 1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.

引用

页码：633 / &

共 12 条

[1]

BIRGE CA, 1967, P SOC EXP BIOL MED, V126, P342

[2]

BRIDSON WE, 1969, DEC M AM FED CLIN RE

[3] HUMAN GROWTH HORMONE - CLINICAL MEASUREMENT RESPONSE TO HYPOGLYCEMIA + SUPPRESSION BY CORTICOSTEROIDS [J].