ABSORPTION ENHANCEMENT OF RECTALLY INFUSED INSULIN BY SODIUM TAURO-24,25-DIHYDROFUSIDATE (STDHF) IN RATS

被引：20

作者：

VANHOOGDALEM, EJ ^{[1
]}

HEIJLIGERSFEIJEN, CD ^{[1
]}

VERHOEF, JC ^{[1
]}

DEBOER, AG ^{[1
]}

BREIMER, DD ^{[1
]}

机构：

[1] LEIDEN STATE UNIV, SYLVIUS LABS,DIV PHARMACOL,CTR BIOPHARMACEUT SCI, POB 9503, 2300 RA LEIDEN, NETHERLANDS

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 02期

关键词：

absorption; insulin; rats; rectum; sodium tauro-24,25-dihydrofusidate;

D O I：

10.1023/A:1015837004307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0.2 ± 0.2 (control) to 4.2 ± 3.2 and 6.7 ± 2.1%, respectively, as assessed by radioimmunoassay. Insulin preparations with STDHF reduced blood glucose concentrations considerably in a concentration-dependent way. Coadministration of STDHF with Na2EDTA (0.25%, w/v) tended to increase further insulin bioavailability and hypoglycemic response. Varying the site of rectal administration did not influence these parameters. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：180 / 183

页数：4

共 25 条

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