THE ABILITY OF INDUCED OSTEO-PROGENITOR CELLS TO MAINTAIN AND REBUILD LONG-TERM ECTOPIC OSTEO-HEMATOPOIETIC FOCI INVITRO

被引：9

作者：

GUREVITCH, OA

机构：

[1] Laboratory for Physiology of Hematopoiesis, All-Union Scientific Centre for Haematology of the USSR, Ministry of Health

来源：

INTERNATIONAL JOURNAL OF CELL CLONING | 1990年 / 8卷 / 02期

关键词：

Hematopoietic microenvironment; Induced osteo‐hematopoietic foci; Tooth matrix;

D O I：

10.1002/stem.5530080206

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tooth matrix particles were implanted s.c. into mice. In six to nine months, fully developed, induced osteo‐hematopoietic foci complete with a cortex and central marrow cavity were formed. The cells from the induced foci were serially retransplanted under the renal capsule of syngeneic recipients. The focus formation was observed during three consecutive passages. The effect was not due to secondary induction. Our data show that the induced osteogenic cells are capable of long‐term maintenance, remodeling and recurrent rebuilding of hematopoietic stroma without an additional application of the inductor. Copyright © 1990 AlphaMed Press

引用

页码：130 / 137

页数：8

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