THE STRUCTURE OF PA48009 - THE REVISED STRUCTURE OF DURAMYCIN

被引：47

作者：

HAYASHI, F ^{[1
]}

NAGASHIMA, K ^{[1
]}

TERUI, Y ^{[1
]}

KAWAMURA, Y ^{[1
]}

MATSUMOTO, K ^{[1
]}

ITAZAKI, H ^{[1
]}

机构：

[1] SHIONOGI & CO LTD, SHIONOGI RES LAB, FUKUSHIMA KU, OSAKA 553, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 11期

关键词：

D O I：

10.7164/antibiotics.43.1421

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

PA48009, a lanthionine-containing peptide antibiotic was isolated from the culture broth of Streptoverticillium griseoverticillatum PA-48009, and identified as duramycin. Determination of the structure using both Edman degradations and 2D NMR spectroscopy showed the need to revise the structure of duramycin given in literature. Duramycin (PA48009) was different from lanthiopeptin (Ro 09-0198, cinnamycin) only by a Lys/Arg exchange at position 2.

引用

页码：1421 / 1430

页数：10

共 13 条

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