MEASUREMENTS OF REGIONAL CEREBRAL BLOOD-FLOW AND COGNITIVE PERFORMANCE IN ALZHEIMERS-DISEASE

被引：135

作者：

MONTALDI, D

BROOKS, DN

MCCOLL, JH

WYPER, D

PATTERSON, J

BARRON, E

MCCULLOCH, J

机构：

[1] UNIV GLASGOW,DEPT PSYCHOL MED,GLASGOW G12 8QQ,SCOTLAND

[2] UNIV GLASGOW,DEPT STAT,GLASGOW G12 8QQ,SCOTLAND

[3] SO GEN HOSP,DEPT CLIN PHYS,GLASGOW G51 4TF,SCOTLAND

[4] UNIV GLASGOW,WELLCOME SURG INST,GLASGOW G12 8QQ,SCOTLAND

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1990年 / 53卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/jnnp.53.1.33

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior-temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.

引用

页码：33 / 38

页数：6

共 23 条

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ANDERSEN AR, 1988, J CEREB BLOOD FLOW M, V8, P544

[2]

BARON JC, 1980, ANN NEUROL, V8, P128

[3] SPECT STUDY OF REGIONAL CEREBRAL BLOOD-FLOW IN ALZHEIMER-DISEASE [J].