VASODILATOR ACTION OF PROSTAGLANDIN-E1 ON MICROCIRCULATION OF RAT CREMASTER MUSCLE

被引：32

作者：

CHEN, LE ^{[1
]}

SEABER, AV ^{[1
]}

URBANIAK, JR ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT SURG,ORTHOPAED RES LABS,DURHAM,NC 27710

来源：

MICROSURGERY | 1990年 / 11卷 / 03期

关键词：

D O I：

10.1002/micr.1920110303

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Vascular spasm is often present after microsurgical procedures, and its presence or absence can greatly influence the success rate of such operations. Prostaglandin E1 (PGE1) is known to be a potent vasodilator and antiaggregator of small blood vessels. Using intravital videomicroscopy in the rat cremaster model, this study visually and quantitatively monitored changes in vessel diameter to observe the effect of PGE1 on the microcirculation and compared its action with that of 1% lidocaine. The results suggest that PGE1 (10 μg/ml) can significantly relieve epinephrine‐induced vasoconstriction at the terminal arteriole, arteriole, and small artery level (vessel diameters 10–50 μm). The vasodilatory action of PGE1 is reflected by an increase in vessel diameter, and PGE1 may have a role in reversing vascular spasm after microsurgery, enhancing the survival rate of replanted extremities. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：204 / 208

页数：5

共 13 条

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