5-METHYLNALOXONE AND 5-METHYLNALTREXONE - SYNTHESIS AND PHARMACOLOGICAL EVALUATION

被引：5

作者：

SCHMIDHAMMER, H

MAYERVALKANOVER, K

WALLAKUGLER, M

机构：

[1] Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Innsbruck, A 6020

来源：

HELVETICA CHIMICA ACTA | 1990年 / 73卷 / 07期

关键词：

D O I：

10.1002/hlca.19900730722

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from 5‐methyl‐oxycodone (6), 5‐methylnaloxone (4), and 5‐methylnaltrexone (5) have been prepared in several steps. Both 4 and 5 behaved as partial agonists in the AcOH writhing agonism and antagonism test in mice. Copyright © 1990 Verlag GmbH & Co. KGaA, Weinheim

引用

收藏

页码：1986 / 1990

页数：5

相关论文

共 19 条

[1] DERIVATIVES OF THE THEBAINE ANION .1. STRUCTURE OF METOPON - A DIRECT DEMONSTRATION [J].

BODEN, RM ;

GATES, M ;

HO, SP ;

SUNDARARAMAN, P .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (07) :1347-1349

[2] NALOXONE REDUCES FOOD-INTAKE IN HUMANS [J].

COHEN, MR ;

COHEN, RM ;

PICKAR, D ;

MURPHY, DL .

PSYCHOSOMATIC MEDICINE, 1985, 47 (02) :132-138

[3] 14-HYDROXYNORCODEINE AND ITS DERIVATIVES [J].

CURRIE, AC ;

SPRING, FS ;

NEWBOLD, GT .

JOURNAL OF THE CHEMICAL SOCIETY, 1961, (NOV) :4693-&

[4] NALOXONE REDUCES DECREASE IN VENTILATION INDUCED BY HYPOXIA IN NEWBORN-INFANTS [J].

DEBOECK, C ;

VANREEMPTS, P ;

RIGATTO, H ;

CHERNICK, V .

JOURNAL OF APPLIED PHYSIOLOGY, 1984, 56 (06) :1507-1511

[5] NALTREXONE, OPIATE ADDICTION, AND ENDORPHINS [J].

GOLD, MS ;

DACKIS, CA ;

POTTASH, ALC ;

STERNBACH, HH ;

ANNITTO, WJ ;

MARTIN, D ;

DACKIS, MP .

MEDICINAL RESEARCH REVIEWS, 1982, 2 (03) :211-246

[6]

GURLL NJ, 1982, J PHARMACOL EXP THER, V220, P621

[7] NALOXONE REVERSAL OF ENDOTOXIN HYPOTENSION SUGGESTS ROLE OF ENDORPHINS IN SHOCK [J].

HOLADAY, JW ;

FADEN, AI .

NATURE, 1978, 275 (5679) :450-451

[8] NALOXONE, A SPECIFIC OPIOID ANTAGONIST, REVERSES CHRONIC IDIOPATHIC CONSTIPATION [J].

KREEK, MJ ;

HAHN, EF ;

SCHAEFER, RA ;

FISHMAN, J .

LANCET, 1983, 1 (8319) :261-262

[9] OPIOID ANTINOCICEPTIVE EFFECTS OF DELTA-RECEPTOR ANTAGONISTS [J].

LEANDER, JD ;

GESELLCHEN, PD ;

MENDELSOHN, LG .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (02) :351-355

[10]

MARTIN WR, 1973, ARCH GEN PSYCHIAT, V28, P784