COMPARATIVE TUMORIGENICITY IN NEWBORN MICE OF CHRYSENE-1,2-DIOL-3,4-EPOXIDES AND 5-ALKYLCHRYSENE-1,2-DIOL-3,4-EPOXIDES

被引:11
作者
AMIN, S
MISRA, B
BRALEY, J
HECHT, SS
机构
[1] Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, NY
关键词
ALKYLCHRYSENE DIOL EPOXIDES; TUMORIGENICITY; NEWBORN MICE;
D O I
10.1016/0304-3835(91)90032-D
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We determined the tumorigenicity in newborn mice of racemic anti-1,2-diol-3,4-epoxides of chrysene, 5-methylchrysene, 5-ethylchrysene and 5-propylchrysene. Among the four diol epoxides, only anti-5-methylchrysene-1,2-diol-3,4-epoxide was highly tumorigenic. It was 15-30 times more potent in induction of pulmonary tumors than the other compounds. The results demonstrate that molecular shape is critical in determining the tumorigenic activity of alkylchrysene diol epoxides. A methyl group in the same bay region as the epoxide ring leads to exceptional activity. This may be a consequence of DNA adduct conformation.
引用
收藏
页码:115 / 118
页数:4
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