A NOVEL SUPER-SECONDARY STRUCTURE OF BETA-PROTEINS - A TRIPLE-STRAND CORNER

被引：26

作者：

EFIMOV, AV

机构：

[1] Institute of Protein Research, Academy of Sciences of Russia, 142292 Pushchino, Moscow Region

来源：

FEBS LETTERS | 1992年 / 298卷 / 2-3期

关键词：

BETA-HAIRPIN; BETA-SHEET; FOLDING; PACKING; RIGHT-HANDED STRUCTURE;

D O I：

10.1016/0014-5793(92)80072-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel super-secondary structure of beta-proteins, denoted here as a triple-strand comer, is considered in this paper. This structure can be represented as an antiparallel triple-strand beta-sheet folded on itself so that the two beta-beta-hairpins are packed approximately orthogonally in different layers and the central strand bends by 90-degrees in the right-handed direction when passing from one layer to the other. In all the triple-strand corners observed in proteins, the first beta-beta-hairpins are right-handed and the second ones are left-handed when viewed from the concave sides of the corners. Arrangement of other beta-strands in the proteins involving the triple-strand corners is also examined.

引用

收藏

页码：261 / 265

页数：5

相关论文

共 24 条

[1] THE REFINED 2.0 A X-RAY CRYSTAL-STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN-INHIBITOR FROM SQUASH SEEDS (CUCURBITA-MAXIMA) - TOPOLOGICAL SIMILARITY OF THE SQUASH SEED INHIBITORS WITH THE CARBOXYPEPTIDASE A INHIBITOR FROM POTATOES [J].

BODE, W ;

GREYLING, HJ ;

HUBER, R ;

OTLEWSKI, J ;

WILUSZ, T .

FEBS LETTERS, 1989, 242 (02) :285-292

[2] MOLECULAR-STRUCTURE OF CRYSTALLINE STREPTOMYCES-GRISEUS PROTEASE-A AT 2.8-A RESOLUTION .2. MOLECULAR-CONFORMATION, COMPARISON WITH ALPHA-CHYMOTRYPSIN AND ACTIVE-SITE GEOMETRY [J].

BRAYER, GD ;

DELBAERE, LTJ ;

JAMES, MNG .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 124 (01) :261-283

[3] CRYSTAL-STRUCTURE OF A BOVINE NEUROPHYSIN-II DIPEPTIDE COMPLEX AT 2.8-A DETERMINED FROM THE SINGLE-WAVELENGTH ANOMALOUS SCATTERING SIGNAL OF AN INCORPORATED IODINE ATOM [J].

CHEN, LQ ;

ROSE, JP ;

BRESLOW, E ;

YANG, D ;

CHANG, WR ;

FUREY, WF ;

SAX, M ;

WANG, BC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4240-4244

[4] COILING OF BETA-PLEATED SHEETS [J].

CHOTHIA, C .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 163 (01) :107-117

[5] RELATIVE ORIENTATION OF CLOSE-PACKED BETA-PLEATED SHEETS IN PROTEINS [J].

CHOTHIA, C ;

JANIN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4146-4150

[6] CONFORMATION OF TWISTED BETA-PLEATED SHEETS IN PROTEINS [J].

CHOTHIA, C .

JOURNAL OF MOLECULAR BIOLOGY, 1973, 75 (02) :295-302

[7] STRUCTURE OF PROTEINS - PACKING OF ALPHA-HELICES AND PLEATED SHEETS [J].

CHOTHIA, C ;

LEVITT, M ;

RICHARDSON, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (10) :4130-4134

[8] ORTHOGONAL PACKING OF BETA-PLEATED SHEETS IN PROTEINS [J].

CHOTHIA, C ;

JANIN, J .

BIOCHEMISTRY, 1982, 21 (17) :3955-3965

[9] ANALYSIS OF THE TERTIARY STRUCTURE OF PROTEIN BETA-SHEET SANDWICHES [J].

COHEN, FE ;

STERNBERG, MJE ;

TAYLOR, WR .

JOURNAL OF MOLECULAR BIOLOGY, 1981, 148 (03) :253-272

[10] REFINED CRYSTAL-STRUCTURE OF GAMMA-CHYMOTRYPSIN AT 1.9 A RESOLUTION - COMPARISON WITH OTHER PANCREATIC SERINE PROTEASES [J].

COHEN, GH ;

SILVERTON, EW ;

DAVIES, DR .

JOURNAL OF MOLECULAR BIOLOGY, 1981, 148 (04) :449-479