CORTICAL HYPOPERFUSION FOLLOWING SPREADING DEPRESSION IS NOT ALTERED BY TIRILAZAD MESYLATE (U-74006F) IN AWAKE RATS

被引：8

作者：

DUCKROW, RB

BEARD, DC

机构：

[1] Department of Medicine, Division of Neurology, The Milton S. Hershey Medical Center, Hershey

来源：

BRAIN RESEARCH | 1992年 / 572卷 / 1-2期

关键词：

REGIONAL CEREBRAL BLOOD FLOW; SPREADING CORTICAL DEPRESSION; TIRILAZAD MESYLATE; RAT;

D O I：

10.1016/0006-8993(92)90488-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The 21-aminosteroid antioxidant tirilazad mesylate (U-74006F) blocks the delayed hypoperfusion associated with spreading cortical depression (SCD) in anesthetized rats. Because the resting vascular tone influences the blood flow response to SCD, the effect of this drug was reassessed in awake rats. In this state, tirilazad mesylate did not eliminate cerebral hypoperfusion following SCD. Oxygen radical-induced lipid peroxidation may not mediate cerebral hypoperfusion after SCD in awake rats.

引用

页码：296 / 299

页数：4

共 17 条

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