ROLE OF KININS IN INFLAMMATORY RESPONSES - PROSPECTS FOR DRUG-THERAPY

被引：7

作者：

RODELL, TC

NAIDOO, Y

BHOOLA, KD

机构：

[1] UNIV NATAL,SCH MED,DEPT EXPTL & CLIN PHARMACOL,CONGELLA 4013,SOUTH AFRICA

[2] CORTECH INC,DENVER,CO

来源：

CLINICAL IMMUNOTHERAPEUTICS | 1995年 / 3卷 / 05期

关键词：

D O I：

10.1007/BF03259501

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Kinins are ubiquitous mediators that produce many of the cardinal manifestations of inflammation, and for that reason are an important target for therapeutic intervention. The cellular effects produced by the vasoactive kinin peptides are mediated by at least 2 different classes of receptors, B-1 and B-2. The development of specific, competitive antagonists of these receptors has provided a powerful tool for elucidating the physiopathological actions of kinins. Considerable evidence from in vitro and animal studies suggests that currently available kinin antagonists are capable of blocking many of the pro-inflammatory effects of kinins. Studies to date in humans are encouraging, but not conclusive. The next few years should provide much information on the clinical potential of this exciting new class of components.

引用

页码：352 / 361

页数：10

共 38 条

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