SPECIFICITY AND BIOLOGICAL DISTRIBUTION OF COENZYME M (2-MERCAPTOETHANESULFONIC ACID)

被引：134

作者：

BALCH, WE ^{[1
]}

WOLFE, RS ^{[1
]}

机构：

[1] UNIV ILLINOIS, DEPT MICROBIOL, URBANA, IL 61801 USA

来源：

JOURNAL OF BACTERIOLOGY | 1979年 / 137卷 / 01期

关键词：

D O I：

10.1128/JB.137.1.256-263.1979

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The specificity of the growth requirement of Methanobacterium ruminantium strain M1 for a new coenzyme, 2-mercaptoethanesulfonic acid (HS-CoM), was examined. A variety of derivatives, analogs and potential biosynthetic precursors of CoM were tested; only a restricted range of thioether, thioester and thiocarbonate derivatives of the cofactor replaced the HS-CoM requirement. Bromoethanesulfonic acid (BrCH2CH2SO3-), a halogenated analog of HS-CoM, potently inhibited the growth response. No coenzyme was detectable in a wide range of nonmethanogenic eukaryotic tissues and prokaryotic organisms. All methanogens available in pure culture exhibited high levels of CoM which ranged from 0.3-16 nmol/mg of dry wt.

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收藏

页码：256 / 263

页数：8

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