EFFECT OF DISULFIRAM ON TURNOVER OF 5-HYDROXYTRYPTAMINE IN RAT-BRAIN

被引：23

作者：

FUKUMORI, R

MINEGISHI, A

SATOH, T

KITAGAWA, H

YANAURA, S

机构：

[1] CHIBA UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM PHARMACOL,CHIBA 280,JAPAN

[2] HOSHI COLL PHARM,DEPT PHARMACOL,TOKYO 142,JAPAN

来源：

LIFE SCIENCES | 1979年 / 25卷 / 02期

关键词：

D O I：

10.1016/0024-3205(79)90383-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Effect of disulfiram on 5-hydroxytryptamine (5-HT) turnover was studied. Treatment with disulfiram caused increases in 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in rat brain. Under the same condition, activity of brain mitochondrial aldehyde dehydrogenase was reduced, however, supernatant aldehyde dehydrogenase and monoamine oxidase activities remained unchanged. Disulfiram had no effect on synthesis rate of 5-HT, but decreased metabolism of 5-HT. Moreover, disulfiram impaired transport of 5-HIAA from brain tissue. © 1979.

引用

页码：123 / 130

页数：8

共 25 条

[1] EFFECTS OF DISULFIRAM AND CHLORAL HYDRATE ON METABOLISM OF CATECHOLAMINES IN RAT-LIVER AND BRAIN [J].