EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-PARA DIOXIN ON INDOCYANINE GREEN BLOOD CLEARANCE IN RHESUS-MONKEYS

被引:8
作者
SEEFELD, MD
ALBRECHT, RM
PETERSON, RE
机构
[1] UNIV WISCONSIN,CTR ENVIRONM TOXICOL,MADISON,WI 53706
[2] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706
关键词
D O I
10.1016/0300-483X(79)90008-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
To assess effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver function adult male rhesus monkeys were treated with a single oral dose of acetone/corn oil (control) or 5, 25, or 75 μg/kg TCDD. Each monkey was used as its own control and indocyanine green (ICG) blood clearance and the following serum enzymes: glutamic pyruvate transaminase (SGPT), sorbitol dehydrogenase (SDH) and gamma glutamyl transpeptidase (γGTP), were measured at regular intervals for 4 weeks before and 17 weeks after treatment. In control monkeys ICG blood clearance and serum enzymes were similar before and after treatment. However, in the monkey that received 5 μg/kg TCDD there was a mild increase in ICG blood clearance followed by a slight decrease. The magnitude of this biphasic change was greater in monkeys that received 25 and 75 μg/kg TCDD and the decrease in clearance was invariably associated with a 1-2-week period before the monkeys died. SDH and SGPT activities were elevated at some time during the course of intoxication in TCDD-treated monkeys but γGTP activity was not altered. The monkey treated with 5 μg/kg TCDD survived but monkeys treated with 25 and 75 μg/kg died 4-6 weeks after treatment. Light microscopy of the livers of TCDD-treated monkeys that died revealed fatty infiltration with minimal hepatocellular necrosis. © 1979.
引用
收藏
页码:263 / 272
页数:10
相关论文
共 25 条
[1]   MORPHOLOGICAL-CHANGES IN MONKEYS CONSUMING A DIET CONTAINING LOW-LEVELS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN [J].
ALLEN, JR ;
BARSOTTI, DA ;
VANMILLER, JP ;
ABRAHAMSON, LJ ;
LALICH, JJ .
FOOD AND COSMETICS TOXICOLOGY, 1977, 15 (05) :401-410
[2]   INDUSTRIALLY ACQUIRED PORPHYRIA [J].
BLEIBERG, J ;
BRODKIN, R ;
WALLEN, M ;
APPLEBAUM, IL .
ARCHIVES OF DERMATOLOGY, 1964, 89 (06) :793-+
[3]   EFFECTS OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN ON DISTRIBUTION AND BILIARY-EXCRETION OF POLYCHLORINATED BIPHENYLS IN RATS [J].
GUINEY, PD ;
YANG, KH ;
SEYMOUR, JL ;
PETERSON, RE .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 45 (02) :403-414
[4]  
Kimbrough R D, 1974, CRC Crit Rev Toxicol, V2, P445
[5]   STRUCTURAL AND FUNCTIONAL STUDIES OF LIGANDIN, A MAJOR RENAL ORGANIC ANION-BINDING PROTEIN [J].
KIRSCH, R ;
FLEISCHNER, G ;
KAMISAKA, K ;
ARIAS, IM .
JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (05) :1009-1019
[6]   PLASMA DISAPPEARANCE AND BILIARY EXCRETION OF INDOCYANINE GREEN IN RATS, RABBITS AND DOGS [J].
KLAASSEN, CD ;
PLAA, GL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1969, 15 (02) :374-&
[7]   2 HEPATIC CYTOPLASMIC PROTEIN FRACTIONS, Y AND Z, AND THEIR POSSIBLE ROLE IN HEPATIC UPTAKE OF BILIRUBIN, SULFOBROMOPHTHALEIN, AND OTHER ANIONS [J].
LEVI, AJ ;
GATMAITAN, Z ;
ARIAS, IM .
JOURNAL OF CLINICAL INVESTIGATION, 1969, 48 (11) :2156-+
[8]  
MAY G, 1973, BRIT J IND MED, V30, P276
[9]   TOXICITY OF "2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN IN RHESUS-MONKEYS (MACACA-MULATTA) FOLLOWING A SINGLE ORAL DOSE [J].
MCCONNELL, EE ;
MOORE, JA ;
DALGARD, DW .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 43 (01) :175-187
[10]  
MCCONNELL EE, 1978, TOXICOL APPL PHARMAC, V44, P353