INDUCIBILITY AND FUNCTIONALITY OF RAT EMBRYONIC FETAL CYTOCHROME-P-450 - A STUDY OF DIFFERENTIATING LIMB-BUD AND MID-BRAIN CELLS-INVITRO

被引：10

作者：

BROWN, LP

FOSTER, JR

ORTON, TC

FLINT, OP

GIBSON, GG

机构：

[1] UNIV SURREY,DEPT BIOCHEM,MOLEC TOXICOL GRP,GUILDFORD GU2 5XH,SURREY,ENGLAND

[2] ICI PLC,CENT TOXICOL LAB,PATHOL SECT,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

[3] ICI PHARMACEUT PLC,DEPT SAFETY MED,MACCLESFIELD SK10 4TJ,CHESHIRE,ENGLAND

[4] BRISTOL MYERS CO,PHARMACEUT RES & DEV,SYRACUSE,NY 13221

来源：

TOXICOLOGY IN VITRO | 1989年 / 3卷 / 04期

关键词：

D O I：

10.1016/0887-2333(89)90031-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

引用

页码：253 / 260

页数：8

共 31 条

[1] CORRELATIONS BETWEEN EMBRYOTOXIC AND GENOTOXIC EFFECTS OF PHENYTOIN IN MICE [J].

BARCELLONA, PS ;

BARALE, R ;

CAMPANA, A ;

ZUCCONI, D ;

ROSSI, V ;

CARANTI, S .

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 1987, 7 (02) :159-168

[2] A MONOCLONAL-ANTIBODY RAISED TO RAT-LIVER CYTOCHROME-P-448 (FORM-C) WHICH RECOGNIZES AN EPITOPE COMMON TO MANY OTHER FORMS OF CYTOCHROME-P-450 [J].

BOOBIS, AR ;

MCQUADE, J ;

SESARDIC, D ;

ROBSON, RT ;

HAYWARD, C ;

LOCK, EA ;

ELCOMBE, CR ;

ROSE, MS ;

DAVIES, DS .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (10) :1671-1681

[3] CHEMICAL TERATOGENESIS - TESTING METHODS AND THE ROLE OF METABOLISM [J].

BROWN, LP ;

FLINT, OP ;

ORTON, TC ;

GIBSON, GG .

DRUG METABOLISM REVIEWS, 1986, 17 (3-4) :221-260

[4] LOCALIZATION AND IDENTIFICATION OF CYTOCHROME-P-450 IN DIFFERENTIATING RAT EMBRYO CELLS-INVITRO AND IN FETAL TISSUE INVIVO BY IMMUNOCYTOCHEMISTRY [J].

BROWN, LP ;

FOSTER, JR ;

ORTON, TC ;

FLINT, OP ;

GIBSON, GG .

TOXICOLOGY IN VITRO, 1989, 3 (04) :245-252

[5] INVITRO METABOLISM OF TERATOGENS BY DIFFERENTIATING RAT EMBRYO CELLS [J].

BROWN, LP ;

FLINT, OP ;

ORTON, TC ;

GIBSON, GG .

FOOD AND CHEMICAL TOXICOLOGY, 1986, 24 (6-7) :737-742

[6]

CONNEY AH, 1960, J PHARMACOL EXP THER, V130, P1

[7]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[8] IMMUNOQUANTIFICATION OF EPOXIDE HYDROLASE AND CYTOCHROME-P-450 ISOZYMES IN FETAL AND ADULT HUMAN-LIVER MICROSOMES [J].

CRESTEIL, T ;

BEAUNE, P ;

KREMERS, P ;

CELIER, C ;

GUENGERICH, FP ;

LEROUX, JP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 151 (02) :345-350

[9]

CRESTEIL T, 1986, J PHARMACOL EXP THER, V236, P269

[10] TERATOGENIC BIOACTIVATION OF CYCLOPHOSPHAMIDE INVITRO [J].

FANTEL, AG ;

GREENAWAY, JC ;

JUCHAU, MR ;

SHEPARD, TH .

LIFE SCIENCES, 1979, 25 (01) :67-72

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