AUTORADIOGRAPHIC VISUALIZATION OF NK-3 TACHYKININ BINDING-SITES IN THE RAT-BRAIN, UTILIZING [H-3] SENKTIDE

被引：71

作者：

STOESSL, AJ

HILL, DR

机构：

[1] MERCK SHARP & DOHME LTD,NEUROSCI RES LABS,HARLOW,ESSEX,ENGLAND

[2] PARKE DAVIS RES LABS,CAMBRIDGE,ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 534卷 / 1-2期

关键词：

5-HT; Autoradiography; Rat; Senktide; Tachykinin;

D O I：

10.1016/0006-8993(90)90105-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The autoradiographic distribution of the selective NK-3 tachykinin agonist [3H]senktide was investigated in rat brain. [3H]Senktide bound with high affinity (KD<2.5 mM) and high specificity (>75%) to cerebral cortex and numerous subcortical sites, including the substantia nigra pars compacta. In addition, moderately dense binding was seen in the median but not the dorsal raphe nucleus, and this was disrupted by 5,7-dihydroxytryptamine (5,7-DHT)-induced destruction of 5-HT neurons. 5,7-DHT lesions did not affect the binding of [3H]senktide to forebrain regions, suggesting that 5-HT terminals are devoid of NK-3 receptors. © 1990.

引用

收藏

页码：1 / 7

页数：7

相关论文

共 35 条

[1] SUBSTANCE-P AND NEUROKININ-A REGULATE BY DIFFERENT MECHANISMS DOPAMINE RELEASE FROM DENDRITES AND NERVE-TERMINALS OF THE NIGROSTRIATAL DOPAMINERGIC-NEURONS [J].

BARUCH, P ;

ARTAUD, F ;

GODEHEU, G ;

BARBEITO, L ;

GLOWINSKI, J ;

CHERAMY, A .

NEUROSCIENCE, 1988, 25 (03) :889-898

[2] QUANTITATIVE AUTORADIOGRAPHIC ANALYSIS OF THE DISTRIBUTION OF BINDING-SITES FOR [I-125] BOLTON HUNTER DERIVATIVES OF ELEDOISIN AND SUBSTANCE-P IN THE RAT-BRAIN [J].

BEAUJOUAN, JC ;

TORRENS, Y ;

SAFFROY, M ;

GLOWINSKI, J .

NEUROSCIENCE, 1986, 18 (04) :857-875

[3] THE TACHYKININS - A FAMILY OF PEPTIDES WITH A BROOD OF RECEPTORS [J].

BUCK, SH ;

BURCHER, E .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (02) :65-68

[4] PHARMACOLOGICAL CHARACTERIZATION AND AUTORADIOGRAPHIC DISTRIBUTION OF BINDING-SITES FOR IODINATED TACHYKININS IN THE RAT CENTRAL-NERVOUS-SYSTEM [J].

BUCK, SH ;

HELKE, CJ ;

BURCHER, E ;

SHULTS, CW ;

ODONOHUE, TL .

PEPTIDES, 1986, 7 (06) :1109-1120

[5] VISUALIZATION OF NEUROKININ-3 RECEPTOR-SITES IN RAT-BRAIN USING THE HIGHLY SELECTIVE LIGAND [H-3] SENKTIDE [J].

DAM, TV ;

ESCHER, E ;

QUIRION, R .

BRAIN RESEARCH, 1990, 506 (01) :175-179

[6] A COMPARATIVE AUTORADIOGRAPHIC STUDY OF THE DISTRIBUTIONS OF SUBSTANCE-P AND ELEDOISIN BINDING-SITES IN RAT-BRAIN [J].

DANKS, JA ;

ROTHMAN, RB ;

CASCIERI, MA ;

CHICCHI, GG ;

LIANG, T ;

HERKENHAM, M .

BRAIN RESEARCH, 1986, 385 (02) :273-281

[7] SUBSTANCE-P IN SUBSTANTIA NIGRA [J].

DAVIES, J ;

DRAY, A .

BRAIN RESEARCH, 1976, 107 (03) :623-627

[8] AUTORADIOGRAPHIC LOCALIZATION OF H-3 PAROXETINE-LABELED SEROTONIN UPTAKE SITES IN RAT-BRAIN [J].

DESOUZA, EB ;

KUYATT, BL .

SYNAPSE, 1987, 1 (05) :488-496

[9] COMPARISON OF THE BINDING OF RADIOLABELED NEUROKININ-A AND ELEDOISIN IN RAT CORTEX SYNAPTIC-MEMBRANES [J].

FOSTER, AC ;

TRIDGETT, R .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (02) :602-608

[10] PHARMACOLOGICAL ANALYSIS OF [H-3] SENKTIDE BINDING TO NK3 TACHYKININ RECEPTORS IN GUINEA-PIG ILEUM LONGITUDINAL MUSCLE-MYENTERIC PLEXUS AND CEREBRAL-CORTEX MEMBRANES [J].

GUARD, S ;

WATSON, SP ;

MAGGIO, JE ;

TOO, HP ;

WATLING, KJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (04) :767-773

← 1 2 3 4 →