EFFECTS OF D600 ON HYPOXIC SUPPRESSION OF K+ CURRENTS IN ISOLATED TYPE-I CAROTID-BODY CELLS OF THE NEONATAL RAT

被引：24

作者：

PEERS, C

机构：

[1] University Laboratory of Physiology, Oxford, OX1 3PT, Parks Rd

来源：

FEBS LETTERS | 1990年 / 271卷 / 1-2期

关键词：

Carotid body; D600; Hypoxia; K[!sup]+[!/sup] current; Patch-clamp; Phenylalkylamine; Verapamil;

D O I：

10.1016/0014-5793(90)80366-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

K+ currents recorded from isolated type I carotid body cells were reversibly suppressed by hypoxia (pO2 25 Torr). Inhibition of Ca2+ influx using high Mg2+, low Ca2+ solutions abolished this effect, indicating hypoxia selectively inhibits the Ca2+-activa ted component of K+ currents. The Ca2+ channel blockers D600 and verapamil reversed the suppressive effects of hypoxia. These drugs also partially inhibited Ca2+-independent K+ currents, but this effect was relieved by hypoxia, causing apparent reversal of hypoxic suppression of the K+ currents seen under control conditions. © 1990.

引用

页码：37 / 40

页数：4

共 11 条

[1]

DECOURSEY TE, 1984, BIOPHYS J, V45, pA144

[2] EVIDENCE FOR A PO2-SENSITIVE K+ CHANNEL IN THE TYPE-I CELL OF THE RABBIT CAROTID-BODY [J].