BETAXOLOL - A NEW LONG-ACTING BETA-1-SELECTIVE ADRENERGIC BLOCKER

被引：10

作者：

FRISHMAN, WH ^{[1
]}

TEPPER, D ^{[1
]}

LAZAR, EJ ^{[1
]}

BEHRMAN, D ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,DIV CARDIOL,BRONX,NY 10461

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 30卷 / 08期

关键词：

D O I：

10.1002/j.1552-4604.1990.tb03627.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Betaxolol (Searle, Skokie, Illinois) is a new beta1‐selective adrenergic blocker with no partial agonist action and minimal membrane stabilizing activity. Its pharmacokinetic profile is characterized by a long serum half‐life and excellent oral bioavailability, with little first‐pass metabolism. The mean 16‐hour half‐life of betaxolol has been shown to provide full 24‐hour control of blood pressure and heart rate. Betaxolol has been proven to be a safe and effective antihypertensive agent, and was recently approved for clinical use in the United States for this indication. 1990 American College of Clinical Pharmacology

引用

页码：686 / 692

页数：7

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