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COMPARISON OF CILOFUNGIN AND AMPHOTERICIN-B FOR THERAPY OF MURINE CANDIDIASIS

被引：7
作者：
SMITH, KR
LANK, KM
COBBS, CG
CLOUD, GA
DISMUKES, WE
机构：
[1] UNIV ALABAMA,BIRMINGHAM SCH MED,DEPT MED,DIV INFECT DIS,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,BIRMINGHAM SCH MED,CTR COMPREHENS CANC,DIV BIOSTAT,BIRMINGHAM,AL 35294
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 08期
关键词：
D O I：
10.1128/AAC.34.8.1619
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P < 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).
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收藏
页码：1619 / 1621
页数：3
相关论文
共 14 条
[1]  
Gordee R S, 1988, Ann N Y Acad Sci, V544, P294, DOI 10.1111/j.1749-6632.1988.tb40415.x
[2]   INVITRO AND INVIVO ANTI-CANDIDA ACTIVITY AND TOXICOLOGY OF LY121019 [J].
GORDEE, RS ;
ZECKNER, DJ ;
ELLIS, LF ;
THAKKAR, AL ;
HOWARD, LC .
JOURNAL OF ANTIBIOTICS, 1984, 37 (09) :1054-1065
[3]   CILOFUNGIN (LY121019), AN ANTIFUNGAL AGENT WITH SPECIFIC ACTIVITY AGAINST CANDIDA-ALBICANS AND CANDIDA-TROPICALIS [J].
HALL, GS ;
MYLES, C ;
PRATT, KJ ;
WASHINGTON, JA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1331-1335
[4]   EVALUATION OF CILOFUNGIN, A LIPOPEPTIDE ANTIFUNGAL AGENT, INVITRO AGAINST FUNGI ISOLATED FROM CLINICAL SPECIMENS [J].
HANSON, LH ;
STEVENS, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (08) :1391-1392
[5]   EVALUATION OF INVITRO ANTIFUNGAL ACTIVITY OF LY121019 [J].
HOBBS, M ;
PERFECT, J ;
DURACK, D .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1988, 7 (01) :77-80
[6]  
MCGINNIS MR, 1986, ANTIBIOTICS LABORATO, P233
[7]   PH AND OTHER EFFECTS ON THE ANTIFUNGAL ACTIVITY OF CILOFUNGIN (LY121019) [J].
MCINTYRE, KA ;
GALGIANI, JN .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (05) :731-735
[8]   ACTIVITY OF CILOFUNGIN (LY121019) AGAINST CANDIDA SPECIES INVITRO [J].
ODDS, FC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (06) :891-897
[9]   EVALUATION OF CILOFUNGIN (LY121019) FOR TREATMENT OF EXPERIMENTAL CANDIDA-ALBICANS ENDOCARDITIS IN RABBITS [J].
PADULA, A ;
CHAMBERS, HF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (10) :1822-1823
[10]   TREATMENT OF EXPERIMENTAL DISSEMINATED CANDIDIASIS WITH CILOFUNGIN [J].
PERFECT, JR ;
HOBBS, MM ;
WRIGHT, KA ;
DURACK, DT .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (10) :1811-1812
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