MULTICATALYTIC PROTEINASE IS PRESENT IN LEWY BODIES AND NEUROFIBRILLARY TANGLES IN DIFFUSE LEWY BODY DISEASE BRAINS

被引：50

作者：

KWAK, S

MASAKI, T

ISHIURA, S

SUGITA, H

机构：

[1] National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 01期

关键词：

LEWY BODY; NEUROFIBRILLARY TANGLE; UBIQUITIN; MULTICATALYTIC PROTEINASE; IMMUNOHISTOCHEMISTRY; DIFFUSE LEWY BODY DISEASE;

D O I：

10.1016/0304-3940(91)90751-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A non-lysosomal multicatalytic proteinase (MCP) is immunohistochemically visualized in Lewy bodies and loosely arranged globose tangles but not in the majority of compact neurofibrillary tangles in brains with cortical diffuse Lewy body disease. Virtually all Lewy bodies are immunoreactive to MCP, exhibiting various staining patterns where they are moderately diffuse, intense in the central core or intense in the peripheral rim. MCP may be involved in the formation of these inclusions.

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页码：21 / 24

页数：4

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