PARTIAL INVERSION OF GENE ORDER WITHIN A HOMOLOGOUS SEGMENT ON THE X-CHROMOSOME

被引：18

作者：

LAVAL, SH ^{[1
]}

BOYD, Y ^{[1
]}

机构：

[1] MRC,RADIOBIOL UNIT,DIV GENET,DIDCOT OX11 ORD,OXON,ENGLAND

来源：

MAMMALIAN GENOME | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1007/BF00290437

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The locus for the erthyroid transcription factor, GATA1, has been positioned in the small interval between DXS255 and TIMP on the proximal short arm of the human X Chromosome (Chr) by use of a partial human cDNA clone and a well-characterized somatic cell hybrid panel. Analysis of selected recombinants from 108 Mus musculus x Mus spretus backcross progeny with the same clone confirmed that the homologous murine locus (Gf-1) lies between Otc and the centromere of the mouse X Chr. These data imply that a partial inversion of gene order has occurred within the conserved segment that represents Xp21.1-Xp11.23 in human (CYBB-GATA1) and the proximal 6 cM of the mouse X Chr (Gf-1-Timp). Furthermore, they indicate that the mouse mutant scurfy and the human genetic disorder Wiskott-Aldrich syndrome, which have been mapped to the same regions as GATA1/Gf-1 in both species, may indeed be homologous disorders.

引用

页码：119 / 123

页数：5

共 32 条

[1] THE HUMAN HOMOLOG OF THE MOUSE BROWN GENE MAPS TO THE SHORT ARM OF CHROMOSOME-9 AND EXTENDS THE KNOWN REGION OF HOMOLOGY WITH MOUSE CHROMOSOME-4
ABBOTT, C
JACKSON, IJ
CARRITT, B
POVEY, S
[J]. GENOMICS, 1991, 11 (02) : 471 - 473
[2] ALDRICH RA, 1954, PEDIATRICS, V13, P133
[3] AMAR L C, 1988, Genomics, V2, P220, DOI 10.1016/0888-7543(88)90006-7
[4] MAPPING OF 12 TRANSLOCATION BREAKPOINTS IN THE XP21 REGION WITH RESPECT TO THE LOCUS FOR DUCHENNE MUSCULAR-DYSTROPHY
BOYD, Y
COCKBURN, D
HOLT, S
MUNRO, E
VANOMMEN, GJ
GILLARD, B
AFFARA, N
FERGUSONSMITH, M
CRAIG, I
[J]. CYTOGENETICS AND CELL GENETICS, 1988, 48 (01): : 28 - 34
[5] MOUSE X-CHROMOSOME
BROWN, SDM
AVNER, P
HERMAN, GE
[J]. MAMMALIAN GENOME, 1992, 3 : S274 - S288
[6] CAIULO A, 1991, HUM GENET, V86, P388
[7] LINKAGE OF THE ERYTHROID TRANSCRIPTION FACTOR GENE (GF-1) TO THE PROXIMAL REGION OF THE X-CHROMOSOME OF MICE
CHAPMAN, VM
STEPHENSON, DA
MULLINS, LJ
KEITZ, BT
DISTECHE, C
ORKIN, SH
[J]. GENOMICS, 1991, 9 (02) : 309 - 313
[8] REPORT OF THE COMMITTEE-ON-THE-GENETIC-CONSTITUTION-OF-THE-X-CHROMOSOME
DAVIES, KE
MANDEL, JL
MONACO, AP
NUSSBAUM, RL
WILLARD, HF
[J]. CYTOGENETICS AND CELL GENETICS, 1991, 58 (1-2): : 853 - 966
[9] AN ERYTHROCYTE-SPECIFIC DNA-BINDING FACTOR RECOGNIZES A REGULATORY SEQUENCE COMMON TO ALL CHICKEN GLOBIN GENES
EVANS, T
REITMAN, M
FELSENFELD, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) : 5976 - 5980
[10] THE ERYTHROID-SPECIFIC TRANSCRIPTION FACTOR ERYF1 - A NEW FINGER PROTEIN
EVANS, T
FELSENFELD, G
[J]. CELL, 1989, 58 (05) : 877 - 885

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