IMPROVED BRAIN DELIVERY OF ANTIVIRAL AGENTS THROUGH THE USE OF REDOX TARGETING

被引：7

作者：

BREWSTER, ME ^{[1
]}

BODOR, N ^{[1
]}

机构：

[1] UNIV FLORIDA, COLL PHARM, J HILLIS MILLER HLTH CTR, CTR DRUG DESIGN & DELIVERY, GAINESVILLE, FL 32610 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1994年 / 14卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

ANTIVIRAL; BLOOD-BRAIN BARRIER; BRAIN-TARGETED DELIVERY; AZIDOTHYMIDINE (ZIDOVUDINE); ACYCLOVIR; GANCICLOVIR; TRIFLUOROTHYMIDINE; RIBAVIRIN;

D O I：

10.1016/0169-409X(94)90038-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inability to effectively deliver antiviral agents to the brain and central nervous system can be overcome via drug latentiation and, specifically, via a redox chemical delivery system. This approach has been successfully applied to a variety of agents, examples of which are summarized in this review. These include azidothymidine, azidouridine, dideoxydidehydrothymidine, acyclovir, trifluorothymidine, gancyclovir and ribavirin.

引用

页码：177 / 197

页数：21

共 53 条

[1] AILLIS L, 1977, ADV CLIN VIROLOGY, P249
[2] BHAGRATH M, 1991, Antiviral Chemistry and Chemotherapy, V2, P265
[3] BLUM MR, 1988, AM J MED, V85, P189
[4] REDOX DRUG DELIVERY SYSTEMS FOR TARGETING DRUGS TO THE BRAIN
BODOR, N
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 507 : 289 - 306
[5] PROBLEMS OF DELIVERY OF DRUGS TO THE BRAIN
BODOR, N
BREWSTER, ME
[J]. PHARMACOLOGY & THERAPEUTICS, 1982, 19 (03) : 337 - 386
[6] BODOR N, 1987, ANNU REP MED CHEM, V22, P303
[7] BODOR N, 1981, Drugs of the Future, V6, P165
[8] SITE-SPECIFIC, SUSTAINED-RELEASE OF DRUGS TO THE BRAIN
BODOR, N
FARAG, HH
BREWSTER, ME
[J]. SCIENCE, 1981, 214 (4527) : 1370 - 1372
[9] BODOR N, 1984, Patent No. 4479932
[10] BODOR N, 1987, CONTROLLED DRUG DELI, P337

← 1 2 3 4 5 6 →