THE PROGNOSTIC VALUE OF SERUM PROGESTERONE AND QUANTITATIVE BETA-HUMAN CHORIONIC-GONADOTROPIN IN EARLY HUMAN-PREGNANCY

被引:38
作者
DAILY, CA [1 ]
LAURENT, SL [1 ]
NUNLEY, WC [1 ]
机构
[1] CAROLINAS MED CTR,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,CHARLOTTE,NC 28232
关键词
PREGNANCY; PROGESTERONE; HUMAN CHORIONIC GONADOTROPIN;
D O I
10.1016/S0002-9378(94)70038-9
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to determine whether serum progesterone, with or without quantitative beta-human chorionic gonadotropin, is predictive of pregnancy outcome within the first 8 weeks of gestation in asymptomatic women. STUDY DESIGN: Asymptomatic patients at <8 menstrual weeks' gestation were prospectively evaluated. The enrollment protocol included history, physical examination, ultrasonographic confirmation, and blood sample collection for beta-human chorionic gonadotropin and progesterone. The association between progesterone and beta-human chorionic gonadotropin values and pregnancy outcome was determined by logistic regression analysis. A receiver-operator characteristic curve was generated on the basis of the sensitivity and specificity of progesterone results. RESULTS: Seventy-four patients were evaluated in this study. The mean serum progesterone level for viable pregnancies was 22.1 ng/ml, which was significantly greater than that for the nonviable gestations, 10.1 ng/ml (p < 0.001). A single progesterone level was predictive of pregnancy outcome (p < 0.001). The probability of an abnormal pregnancy outcome with a serum progesterone level less than or equal to 6 ng/ml was 81%. A single beta-human chorionic gonadotropin level did not contribute to the prediction of pregnancy outcome (p = 0.59). CONCLUSIONS: Serum progesterone alone, within the first 8 weeks of gestation, is predictive of pregnancy outcome.
引用
收藏
页码:380 / 384
页数:5
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