Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy in a patient with HIV infection

被引：11

作者：

Inui, K ^{[1
]}

Miyagawa, H ^{[1
]}

Sashihara, J ^{[1
]}

Miyoshi, H ^{[1
]}

Tanaka-Taya, K ^{[1
]}

Nishigaki, T ^{[1
]}

Teraoka, S ^{[1
]}

Mano, T ^{[1
]}

Ono, J ^{[1
]}

Okada, S ^{[1
]}

机构：

[1] Osaka Univ, Fac Med, Dept Pediat, Osaka 5650871, Japan

来源：

BRAIN & DEVELOPMENT | 1999年 / 21卷 / 06期

关键词：

progressive multifocal leukoencephalopathy; HIV infection; highly active antiretroviral therapy; papovavirus JC;

D O I：

10.1016/S0387-7604(99)00038-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease resulting from lytic infection of oligodendrocytes by the papovavirus JC (JCV). PML has also been recognized as an AIDS-defining-illness. The incidence of MML has increased since 1987 and it occurs in up to 4% of patients with AIDS. To date, there is no treatment available for PML and it usually results in death within 3-6 months of diagnosis. However, there are some reports of remission of PML after antiretroviral therapy. We report a 12-year-old child with hemophilia B and developing AIDS with the onset of PML. With highly active antiretroviral therapy, PML subsided with an increase of CD4 count from 10 to 30/mu l in spite of about 1.0 x 10(4) human immunodeficiency virus (HIV)-1-RNA copies. He has survived more than 1 year without specific therapy against JCV. Highly active antiretroviral therapy appears to have improved his prognosis in HIV-associated PML. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：416 / 419

页数：4

共 19 条

[1] Highly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathy [J].