DEVELOPMENT OF RESISTANCE IN PSEUDOMONAS-AERUGINOSA TO BROAD-SPECTRUM CEPHALOSPORINS VIA STEP-WISE MUTATIONS

被引:21
作者
GRADELSKI, E
FUNGTOMC, J
HUCZKO, E
KESSLER, RE
机构
[1] Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT
关键词
D O I
10.1093/jac/32.suppl_B.75
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Step-wise resistance to cefepime, ceftazidime, cefotaxime, and cefpirome were determined for 16 Pseudomonas aeruginosa strains by daily transfer for 7 days to fresh media containing two-fold serial dilution of antibiotic. By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to ceftazidime compared with none, five (31%) and ten (60%) strains becoming resistant to cefepime, cefpirome and cefotaxime (MIC ≥ 64 mg/L), respectively. At the end of the 7 day serial transfer, only four (25%) of the 16 strains were resistant to cefepime, in contrast to nine (56%) cefpirome resistant, 12 (75%) ceftazidime resistant and 13 (81%) cefotaxime resistant. These results are consistent with the infrequent, single-step development of resistance to cefepime, and this may also explain the frequent cefepime susceptibility of cefotaxime/ceftazidime-resistant clinical isolates of P. aeruginosa. © 1993 The British Society for Antimicrobial Chemotheraphy.
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页码:75 / 80
页数:6
相关论文
共 16 条
[1]   FACTORS THAT INFLUENCE THE EVOLUTION OF BETA-LACTAM RESISTANCE IN BETA-LACTAMASE - INDUCIBLE STRAINS OF ENTEROBACTER-CLOACAE AND PSEUDOMONAS-AERUGINOSA [J].
ARONOFF, SC ;
SHLAES, DM .
JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (05) :936-941
[2]   SELECTION FREQUENCY OF RESISTANT VARIANTS BY VARIOUS BETA-LACTAM ANTIBIOTICS IN CLINICAL ENTEROBACTER-CLOACAE ISOLATES [J].
BUSCHER, KH ;
CULLMANN, W ;
DICK, W ;
STIEGLITZ, M .
CHEMOTHERAPY, 1987, 33 (01) :40-51
[3]   CEFPIROME (HR 810) - LACK OF SELECTION OF BETA-LACTAMASE OVERPRODUCING VARIANTS [J].
CULLMANN, W ;
DICK, W .
JOURNAL OF ANTIBIOTICS, 1985, 38 (07) :912-919
[4]   ORIGIN OF BACTERIAL RESISTANCE TO ANTIBIOTICS [J].
DEMEREC, M .
JOURNAL OF BACTERIOLOGY, 1948, 56 (01) :63-74
[5]   SUSCEPTIBILITY OF ENTEROBACTER TO CEFAMANDOLE - EVIDENCE FOR A HIGH MUTATION-RATE TO RESISTANCE [J].
FINDELL, CM ;
SHERRIS, JC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 9 (06) :970-974
[6]   ACTIVITY OF CEFEPIME AGAINST CEFTAZIDIME-RESISTANT AND CEFOTAXIME-RESISTANT GRAM-NEGATIVE BACTERIA AND ITS RELATIONSHIP TO BETA-LACTAMASE LEVELS [J].
FUNGTOMC, J ;
DOUGHERTY, TJ ;
DEORIO, FJ ;
SIMICHJACOBSON, V ;
KESSLER, RE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) :498-502
[7]   FREQUENCY OF INVITRO RESISTANCE OF PSEUDOMONAS-AERUGINOSA TO CEFEPIME, CEFTAZIDIME, AND CEFOTAXIME [J].
FUNGTOMC, J ;
HUCZKO, E ;
PEARCE, M ;
KESSLER, RE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1443-1445
[8]   ACTIVITY OF CEFEPIME (BMY-28142) AND CEFPIROME (HR 810) AGAINST GRAM-NEGATIVE BACILLI RESISTANT TO CEFOTAXIME OR CEFTAZIDIME [J].
JONES, RN ;
FUCHS, PC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 23 (01) :163-165
[9]   DEVELOPMENT OF BETA-LACTAM RESISTANT ENTEROBACTER-CLOACAE IN MICE [J].
MARCHOU, B ;
MICHEAHAMZEHPOUR, M ;
LUCAIN, C ;
PECHERE, JC .
JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (02) :369-373
[10]   DEVELOPMENT OF RESISTANCE DURING CEFTAZIDIME AND CEFEPIME THERAPY IN A MURINE PERITONITIS MODEL [J].
PECHERE, JC ;
VLADOIANU, IR .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 29 (05) :563-573