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DEVELOPMENT OF RESISTANCE IN PSEUDOMONAS-AERUGINOSA TO BROAD-SPECTRUM CEPHALOSPORINS VIA STEP-WISE MUTATIONS
被引:21
作者:
GRADELSKI, E
FUNGTOMC, J
HUCZKO, E
KESSLER, RE
机构:
[1] Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT
关键词:
D O I:
10.1093/jac/32.suppl_B.75
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
Step-wise resistance to cefepime, ceftazidime, cefotaxime, and cefpirome were determined for 16 Pseudomonas aeruginosa strains by daily transfer for 7 days to fresh media containing two-fold serial dilution of antibiotic. By the third transfer 4 of 16 strains (25%) were resistant (MIC ≥ 32 mg/L) to ceftazidime compared with none, five (31%) and ten (60%) strains becoming resistant to cefepime, cefpirome and cefotaxime (MIC ≥ 64 mg/L), respectively. At the end of the 7 day serial transfer, only four (25%) of the 16 strains were resistant to cefepime, in contrast to nine (56%) cefpirome resistant, 12 (75%) ceftazidime resistant and 13 (81%) cefotaxime resistant. These results are consistent with the infrequent, single-step development of resistance to cefepime, and this may also explain the frequent cefepime susceptibility of cefotaxime/ceftazidime-resistant clinical isolates of P. aeruginosa. © 1993 The British Society for Antimicrobial Chemotheraphy.
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页码:75 / 80
页数:6
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