FUROXANS AS NITRIC-OXIDE DONORS - 4-PHENYL-3-FUROXANCARBONITRILE - THIOL-MEDIATED NITRIC-OXIDE RELEASE AND BIOLOGICAL EVALUATION

被引：131

作者：

MEDANA, C

ERMONDI, G

FRUTTERO, R

DISTILO, A

FERRETTI, C

GASCO, A

机构：

[1] UNIV TURIN,DIPARTIMENTO SCI & TECNOL FARMACO,I-10125 TURIN,ITALY

[2] IST FARMACOL & TERAPIA SPERIMENTALE,I-10126 TURIN,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 25期

关键词：

D O I：

10.1021/jm00051a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-Phenyl-3-furoxancarbonitrile (2) affords nitric oxide under the action of thiol cofactors. Two principal products were isolated in the reaction with thiophenol: the phenylcyanoglyoxime (6) and 5-amino-3-phenyl-4-(phenylthio)isoxazol (7). Mechanisms which could account for the formation of these two products are discussed. Compound 2 is an efficient activator of the rat lung soluble guanylate cyclase, displays high vasodilatory activity on strips of rat thoracic aorta precontracted with noradrenaline, and is a potent inhibitor of platelet aggregation.

引用

页码：4412 / 4416

页数：5

共 15 条

[1]

ALEXANIAN V, 1981, HETEROCYCLES, V16, P391

[2] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].