1-(FLUOROBENZYL)-4-AMINO-1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINES - SYNTHESIS AND ANTICONVULSANT ACTIVITY

被引：130

作者：

KELLEY, JL ^{[1
]}

KOBLE, CS ^{[1
]}

DAVIS, RG ^{[1
]}

MCLEAN, EW ^{[1
]}

SOROKO, FE ^{[1
]}

COOPER, BR ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,DIV PHARMACOL,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 20期

关键词：

D O I：

10.1021/jm00020a030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 will be free of emesis and useful in the treatment of seizure disorders for which phenytoin is presently indicated.

引用

页码：4131 / 4134

页数：4

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