Emerging role of microRNA-21 in cancer

被引：387

作者：

Feng, Yin-Hsun ^{[1
,2
]}

Tsao, Chao-Jung ^{[3
]}

机构：

[1] Chi Mei Med Ctr, Div Hematol & Oncol, Dept Internal Med, 901 Chung Hwa Rd, Tainan 71004, Taiwan

[2] Chung Hwa Univ Med Technol, Dept Nursing, Coll Med & Life Sci, Tainan 71703, Taiwan

[3] Chi Mei Med Ctr, Dept Hematol & Oncol, 201 Taikang Village, Tainan 73657, Taiwan

来源：

BIOMEDICAL REPORTS | 2016年 / 5卷 / 04期

关键词：

microRNA-21; carcinogenesis; hematological malignancy;

D O I：

10.3892/br.2016.747

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15-27 nucleotides in length that regulate gene expression at the post-translational level. miR-21 is one of the earliest identified cancer-promoting oncomiRs', targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion. The regulation of miR-21 and its role in carcinogenesis have been extensively investigated. Recent studies have focused on the diagnostic and prognostic value of miR-21 as well as its implication in the drug resistance of human malignancies. The further use of miR-21 as a biomarker and target for cancer treatments is likely to improve the outcome for patients with cancer. The present review highlights recent findings associated with the importance of miR-21 in hematological and non-hematological malignancies.

引用

页码：395 / 402

页数：8

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