INHIBITION OF HISTAMINE-RELEASE AND IONOPHORE-INDUCED CALCIUM FLUX IN RAT MAST-CELLS BY LIDOCAINE AND CHLORPROMAZINE

被引：35

作者：

JOHNSON, HG

MILLER, MD

机构：

[1] Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, 49001, MI

来源：

AGENTS AND ACTIONS | 1979年 / 9卷 / 03期

关键词：

D O I：

10.1007/BF01966694

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We studied the effects of lidocaine (L) and chlorpromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and45calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentrations caused enhancement in this function. Evidence was obtained that L 10-4M may displace Ca++ from the cell membranes. © 1979 Birkhäuser-Verlag.

引用

页码：239 / 243

页数：5

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