C-11-LABELED RADIOPHARMACEUTICALS - SYNTHESIS AND HIGH-PRESSURE LIQUID-CHROMATOGRAPHY OF NICOTINIC-C-11 ACID AMIDE

被引：7

作者：

MACHULLA, HJ

DUTSCHKA, K

机构：

[1] Institut Für Chemie, Kernforschungsanlage Jülich Gmbh, Institut, Jülich

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 02期

关键词：

High Pressure Liquid Chromatography; Radiopharmaceuticals; Carboxyl‐[!sup]11[!/sup]C]‐Nicotinic Acid Amide;

D O I：

10.1002/jlcr.2580160208

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Starting with 11CO2, [carboxyl-11C]-nicotinic acid amide was synthesized via 3-pyridyl-lithium in practically carrier-free amounts within 60 min. Overall radiochemical yields between 20% and 30% were obtained. Identification and purification of the labeled product was carried out by high pressure liquid chromatography using H2O as eluent.

引用

页码：287 / 293

页数：7

共 6 条

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