CHOLINE ADMINISTRATION - CENTRAL EFFECT MEDIATED BY STIMULATION OF ACETYLCHOLINE SYNTHESIS

被引:30
作者
HAUBRICH, DR
PFLUEGER, AB
机构
[1] Neuropsychopharmacology Section Merck Institute for Therapeutic Research West Point
关键词
D O I
10.1016/0024-3205(79)90041-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Oral administration of either choline or physostigmine to rats stimulated the metabolism of dopamine in brain. Treatment of rats with an acetylcholine receptor blocker (atropine) or an inhibitor of acetylcholine synthesis [4-(1-naphthylvinyl) pyridine] antagonized the choline-induced increase in dopamine metabolism. In contrast to its effect on the choline-induced increase in dopamine metabolism, 4-(1-naphthylvinyl) pryridine did not prevent the increase induced by physostigmine. These results indicate that oral administration of choline augments central cholinergic function, and suggest that the mechanism involves stimulation of the rate of synthesis and release of acetylcholine. © 1979.
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页码:1083 / 1090
页数:8
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