ATENOLOL AND CHLORTHALIDONE IN COMBINATION FOR HYPERTENSION

被引:31
作者
BATEMAN, DN [1 ]
DEAN, CR [1 ]
MUCKLOW, JC [1 ]
BULPITT, CJ [1 ]
DOLLERY, CT [1 ]
机构
[1] ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0HS,ENGLAND
关键词
D O I
10.1111/j.1365-2125.1979.tb00946.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 The hypotensive effect of single daily dosing with atenolol 100 mg and chlorthalidone 25 mg given alone or in combination has been assessed in a double‐blind, crossover, placebo controlled trial in fifteen hypertensive patients. 2 Average lying blood pressures were: Placebo 155.4/103.9 mm Hg, atenolol 134.6/85.8 mm Hg, chlorthalidone 139.5/90.1 mm Hg, combination 127.7/82.5 mm Hg. 3 The effect of the combination therapy in reducing lying diastolic pressure compared with placebo (a fall of 21.4 mm Hg) was significantly less than the 31.9 mm Hg fall predicted from the sum of the individual effects (P = 0.01). 4 Observations on blood pressure at rest and under mental, isometric and bicycle ergometer stress were made pre‐dose and post‐dose for a 12 h period at the end of the last treatment period. 5 Lying blood pressure declined from the zero hour (pre‐dose) reading on all treatments to a low at 15.00–18.00 h and then rose again. 6 The rise in systolic blood pressure after isometric exercise and mental stress was of a similar magnitude with all four treatment regimes. 7 Atenolol, alone and in combination with chlorthalidone, reduced the blood pressure and the pulse rate increase on exercise 2 h post‐dose when compared with readings 24 h post‐dose. 8 Once daily dosing with a combination of atenolol and chlorthalidone produced a fall in supine blood pressure over a 24 h period but the effect on exercise induced changes was not uniform over this period. 1979 The British Pharmacological Society
引用
收藏
页码:357 / 363
页数:7
相关论文
共 15 条
[1]  
ARMITAGE P, 1971, STATISTICAL METHODS, P226
[2]  
BARRETT AM, 1973, BRIT J PHARMACOL, V48, P340
[3]   SYMPTOM QUESTIONNAIRE FOR HYPERTENSIVE PATIENTS [J].
BULPITT, CJ ;
DOLLERY, CT ;
CARNE, S .
JOURNAL OF CHRONIC DISEASES, 1974, 27 (06) :309-323
[4]  
CHALMERS J, 1976, LANCET, V2, P328
[5]  
CRANSTON WI, 1963, LANCET, V2, P966
[6]   ONCE-DAILY DOSING WITH ATENOLOL IN PATIENTS WITH MILD OR MODERATE HYPERTENSION [J].
DOUGLASJONES, AP ;
CRUICKSHANK, JM .
BRITISH MEDICAL JOURNAL, 1976, 1 (6016) :990-991
[7]  
Gatley M S, 1968, J R Coll Gen Pract, V16, P39
[8]  
HAYNES RB, 1976, LANCET, V1, P1265
[9]  
HETTIARACHCHI J, 1977, CLIN PHARMACOL THER, V22, P58
[10]  
JEFFERS TA, 1977, BRIT J CLIN PHARMACO, V4, P523, DOI 10.1111/j.1365-2125.1977.tb00780.x