COMPARISON OF GASTRO-INTESTINAL EFFECTS OF ASPIRIN AND FENOPROFEN - DOUBLE-BLIND CROSSOVER STUDY

被引：42

作者：

CHERNISH, SM

ROSENAK, BD

BRUNELLE, RL

CRABTREE, R

机构：

[1] ELI LILLY & CO,LILLY RES LAB,STAT MATH SERV,INDIANAPOLIS,IN 46206

[2] INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46204

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 04期

关键词：

D O I：

10.1002/art.1780220410

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sixteen men received 3904 mg of aspirin, 2400 mg of fenoprofen, or placebo daily for 1 week in a double blind and crossover trial. Fecal blood loss was measured by 51Cr labeled red cells; gastric and duodenal pathology were observed endoscopically. There was more (P < 0.05) blood loss (4.96 ml) after aspirin than after fenoprofen (2.46 ml) or placebo (0.79 ml). By endoscopic examination, aspirin induced more (P < 0.05) gastrointestinal pathology than fenoprofen or placebo, and there was a correlation of 0.70 between the two methods used in this study. Copyright © 1979 American College of Rheumatology

引用

页码：376 / 383

页数：8

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