METABOLISM OF 5-ALPHA-ANDROSTANE-3-BETA,17-BETA-DIOL TO 17-BETA-HYDROXY-5-ALPHA-ANDROSTAN-3-ONE AND 5-ALPHA-ANDROSTAN-3-ALPHA,17-BETA-DIOL IN THE RAT

被引：10

作者：

SUNDE, A

ROSNESS, PA

EIKNES, KB

机构：

[1] Institute of Biophysics, University of Trondheim

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 574卷 / 02期

关键词：

(Rat testis); Androstanediol; Steroid metabolism;

D O I：

10.1016/0005-2760(79)90005-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Significant metabolism of 5α-androstane-3β,17β-diol to 17β-hydroxy-5α-androstan-3-one was recorded in several tissues and organs from rats and humans. This bioconversion was further investigated in rat testis homogenates. 5α-Androstane-3β,17β-diol was readily metabolized to 17β-hydroxy-5α-androstan-3-one with NAD and/or NADP added as cofactors. When a NADPH generating system was included in the incubation, 5α-androstane-3β,17β-diol was metabolized to 5α-androstan-3α,17β-diol. Only small amounts of 17β-hydroxy-5α-androstan-3-one accumulated under the latter condition. © 1979.

引用

页码：240 / 247

页数：8

共 23 条

[1] METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS .3. METABOLISM OF 5-ALPHA-ANDROSTANE-3,17-DIONE, OF 5-ALPHA-ANDROSTANE-3-ALPHA,17-BETA-DIOL AND OF 5-ALPHA-ANDROSTANE-3-BETA,17-BETA-DIOL IN TARGET ORGANS AND PERIPHERAL TISSUES [J].