ABERRANT CYTOPLASMIC EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN IN HODGKINS-DISEASE

被引：40

作者：

BENJAMIN, DR

GOWN, AM

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PATHOL,SEATTLE,WA 98195

[2] UNIV WASHINGTON,SCH MED,DEPT LAB MED & PEDIAT,SEATTLE,WA 98195

来源：

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 1991年 / 15卷 / 08期

关键词：

HODGKINS DISEASE; LYMPH NODES; PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA);

D O I：

10.1097/00000478-199108000-00006

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

During a study using a monoclonal antibody directed against proliferating cell nuclear antigen (PCNA) to assess the proliferative activity of tumors, it was noted that the cytoplasm of Reed-Sternberg (RS) cells and variants of these cells in cases of Hodgkin's disease reacted very positively. This aberrant expression of PCNA has not been observed in any other tumor or in cells from normal tissues. The biological significance of this observation is currently unknown, but it may have diagnostic utility in detecting and identifying RS cells.

引用

页码：764 / 768

页数：5

共 14 条

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