HYPOGLYCEMIC EFFECTS OF A BETA-AGONIST, RO 16-8714, IN STREPTOZOTOCIN-DIABETIC RATS - DECREASED HEPATIC GLUCOSE-PRODUCTION AND INCREASED GLUCOSE-UTILIZATION IN OXIDATIVE MUSCLES

被引：7

作者：

FERRE, P

PENICAUD, L

HITIER, Y

MEIER, M

GIRARD, J

机构：

[1] CNRS,PHYSIOL DEV LAB,URA 307,F-75005 PARIS,FRANCE

[2] HOFFMANN LA ROCHE AG,DEPT PHARMACEUT RES,BASEL,SWITZERLAND

[3] CNRS,CTR RECH NUTR,F-92190 MEUDON,FRANCE

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1992年 / 41卷 / 02期

关键词：

D O I：

10.1016/0026-0495(92)90149-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Streptozotocin (STZ)-induced diabetic rats are glycosuric, hyperglycemic, hyperketonemic, overproduce glucose, and have a decreased glucose utilization in oxidative muscles. Treatment with a β-agonist, Ro 16-8714, decreases the glycosuria, hyperglycemia, hyperketonemia, and hepatic glucose production. Tissue glucose utilization was unchanged, except in oxidative muscles, where it was increased. © 1992.

引用

页码：180 / 183

页数：4

共 27 条

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