STEREOCONTROLLED SYNTHESIS OF THE 4-HYDROXY-5-METHYL-2(3H)-DIHYDROFURANONE ISOMERS

被引：10

作者：

AFONSO, CAM

BARROS, MT

GODINHO, LS

MAYCOCK, CD

机构：

[1] UNIV NOVA LISBOA, DEPT CHEM, P-2825 MONTE DE CAPARICA, PORTUGAL

[2] UNIV LISBON, DEPT CHEM, P-1700 LISBON, PORTUGAL

[3] CTR TECNOL QUIM & BIOL, P-2780 OEIRAS, PORTUGAL

来源：

TETRAHEDRON | 1993年 / 49卷 / 20期

关键词：

D O I：

10.1016/S0040-4020(01)85744-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of all four stereoisomers of 4-hydroxy-5-methyl-2(3H)-dihydrofuranone was achieved in 6 or 7 steps with an overall yield of 19% to 23% from a common starting material. The source of chirality being derived from stereoselective bakers' yeast reductions of carbonyl groups.

引用

收藏

页码：4283 / 4292

页数：10

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