CARDIOVASCULAR ACTIONS OF ANGIOTENSIN(1-7)

被引：175

作者：

BENTER, IF

DIZ, DI

FERRARIO, CM

机构：

[1] Hypertension Center, The Bowman Gray School of Medicine, Wake Forest University, Winston-Salem

来源：

PEPTIDES | 1993年 / 14卷 / 04期

关键词：

ARTERIAL PRESSURE; ANGIOTENSIN-II; ANGIOTENSIN PEPTIDES; BLOOD PRESSURE; PROSTACYCLINS;

D O I：

10.1016/0196-9781(93)90097-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +/- 1 mmHg) and the duration (range: 83 +/- 13 to 255 +/- 17 s) of the depressor response correlated with the dose of peptide. Indomethacin (5 mg/kg) eliminated the depressor component. Only [Sar1,Thr8]Ang II inhibited the effect of Ang(1-7) completely. We conclude that angiotensin(1-7) possesses myotonic actions that are in part related to release of vasodilator prostaglandins through an angiotensin receptor other than AT1 or AT2.

引用

页码：679 / 684

页数：6

共 22 条

[1]

THE 3-7 FRAGMENT OF ANGIOTENSIN-II IS PROBABLY RESPONSIBLE FOR ITS PSYCHOACTIVE PROPERTIES [J].