INTERLEUKIN-5 EXPRESSED BY A RECOMBINANT VIRUS VECTOR ENHANCES SPECIFIC MUCOSAL IGA RESPONSES IN-VIVO

被引:53
作者
RAMSAY, AJ
KOHONENCORISH, M
机构
[1] Viral Engineering and Cytokine Research Group, John Curtin School of Medical Research, Australian National University, Canberra
关键词
INTERLEUKIN-5; MUCOSAL IGA RESPONSES; MURINE B-CELLS; RECOMBINANT VACCINIA VIRUS;
D O I
10.1002/eji.1830231215
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Several in vitro studies have shown that murine interleukin-5 (mIL-5) enhances IgA production by activated mucosal B cells. To date, however, there is no evidence that this factor significantly up-regulates mucosal IgA responses in vivo. Here, we show that expression of the gene for mIL-5 in a recombinant vaccinia virus vector markedly increases IgA responses to co-expressed heterologous antigen in the lungs of mice given intranasal inocula of the virus. The elevated local IgA responses to vectors expressing mIL-5 peaked at a fourfold higher level than those elicited by control virus at 14 days after infection and were sustained for at least 4 weeks. Increased IgA responses were abrogated in mice treated with monoclonal antibody against mIL-5 and were not detected in systemic lymphoid tissue. No enhancement of specific IgG levels was found either locally or systemically. Our results indicate that mIL-5 selectively enhances the development of mucosal IgA responses in vivo and suggest that expression of this factor in mucosal vaccine vectors may stimulate local immune reactivity.
引用
收藏
页码:3141 / 3145
页数:5
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