SOLID-PHASE EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THERAPEUTIC MONITORING OF HALOPERIDOL LEVELS

被引:9
作者
HOFFMAN, DW
EDKINS, RD
机构
[1] Neurochemistry Laboratory, Dartmouth Medical School, Lebanon, NH
关键词
HALOPERIDOL; ANTIPSYCHOTIC; THERAPEUTIC DRUG MONITORING; NEUROLEPTIC; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;
D O I
10.1097/00007691-199410000-00011
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
This laboratory has developed a simple and efficient solid-phase extraction method that is combined with a high-performance liquid chromatographic method for rapid and precise therapeutic monitoring of haloperidol (Haldol) blood levels. The solid-phase extraction utilizes a mixed bed column. Sensitivity of the chromatographic method is 0.5 ng/ml (1.3 nM) of drug in serum, and separations can be performed in a 15-min chromatographic run. Advantages of this approach include enhanced speed, sensitivity, and efficiency. A high level of sensitivity may be achieved because of the absence of interferences from other drugs, metabolites, or serum components.
引用
收藏
页码:504 / 508
页数:5
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