Z-GLN(TRT)-AIB-AIB-AIB-OME SYNTHESIS USING UNCA AND BOP PYBROP COUPLING METHODS

被引：24

作者：

AUVINGUETTE, C ^{[1
]}

FREROT, E ^{[1
]}

COSTE, J ^{[1
]}

REBUFFAT, S ^{[1
]}

JOUIN, P ^{[1
]}

BODO, B ^{[1
]}

机构：

[1] CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,F-34094 MONTPELLIER 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(00)60446-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The steric hindered Aib-Aib-Aib tripeptide was synthesized in mild conditions, using PyBroP the coupling of two Aib and Fmoc-Aib-NCA for the generation of the tripeptide, which was obtained with an excellent yield in THF. The coupling of Gln was carried out in the presence of BOP.

引用

页码：2481 / 2482

页数：2

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