EARLY ANTIRETROVIRAL THERAPY

被引：5

作者：

COOPER, DA

机构：

来源：

AIDS | 1994年 / 8卷

关键词：

ANTIRETROVIRALS; EARLY INITIATION;

D O I：

10.1097/00002030-199409001-00003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: To review evidence suggesting that antiretroviral therapy should be initiated at an early stage in HIV infection. Method: Review of published data. Conclusions: There are arguments both for and against early antiretroviral therapy. Although the reasons against are undoubtedly valid, evidence of greater efficacy, less toxicity and a delay in the development of resistance outweigh the possible disadvantages. Moreover, for some patients, early therapy may provide a chance of future benefits from more useful but currently untried treatments.

引用

页码：S9 / S14

页数：6

共 16 条

[1] A COMPARATIVE TRIAL OF DIDANOSINE OR ZALCITABINE AFTER TREATMENT WITH ZIDOVUDINE IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

ABRAMS, DI ;

GOLDMAN, AI ;

LAUNER, C ;

KORVICK, JA ;

NEATON, JD ;

CRANE, LR ;

GRODESKY, M ;

WAKEFIELD, S ;

MUTH, K ;

KORNEGAY, S ;

COHN, DL ;

HARRIS, A ;

LUSKINHAWK, R ;

MARKOWITZ, N ;

SAMPSON, JH ;

THOMPSON, M ;

DEYTON, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (10) :657-662

[2] ZIDOVUDINE NOW OR LATER [J].

BARTLETT, JG .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (05) :351-352

[3] ZIDOVUDINE IN PERSONS WITH ASYMPTOMATIC HIV-INFECTION AND CD4+ CELL COUNTS GREATER-THAN 400 PER CUBIC MILLIMETER [J].

COOPER, DA ;

GATELL, JM ;

KROON, S ;

CLUMECK, N ;

MILLARD, J ;

GOEBEL, FD ;

BRUUN, JN ;

STINGL, G ;

MELVILLE, RL ;

GONZALEZLAHOZ, J ;

STEVENS, JW ;

FIDDIAN, AP .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (05) :297-303

[4]

DEGRUTTOLA V, 1993, J ACQ IMMUN DEF SYND, V6, P359

[5]

DOLIN R, 1993, 9 INT C AIDS BERL

[6] MULTIFACTORIAL NATURE OF HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE - IMPLICATIONS FOR THERAPY [J].

FAUCI, AS .

SCIENCE, 1993, 262 (5136) :1011-1018

[7] THE SAFETY AND EFFICACY OF ZIDOVUDINE (AZT) IN THE TREATMENT OF SUBJECTS WITH MILDLY SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV) INFECTION - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

HANSEN, N ;

COLLIER, AC ;

CAREY, JT ;

PARA, MF ;

HARDY, WD ;

DOLIN, R ;

POWDERLY, WG ;

ALLAN, JD ;

WONG, B ;

MERIGAN, TC ;

MCAULIFFE, VJ ;

HYSLOP, NE ;

RHAME, FS ;

BALFOUR, HH ;

SPECTOR, SA ;

VOLBERDING, P ;

PETTINELLI, C ;

ANDERSON, J .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (10) :727-737

[8] THE EFFICACY OF AZIDOTHYMIDINE (AZT) IN THE TREATMENT OF PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL [J].

FISCHL, MA ;

RICHMAN, DD ;

GRIECO, MH ;

GOTTLIEB, MS ;

VOLBERDING, PA ;

LASKIN, OL ;

LEEDOM, JM ;

GROOPMAN, JE ;

MILDVAN, D ;

SCHOOLEY, RT ;

JACKSON, GG ;

DURACK, DT ;

KING, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (04) :185-191

[9]

FISCHL MA, 1993, 9TH INT C AIDS BERL

[10]

GRAHAM NMH, 1993, J ACQ IMMUN DEF SYND, V6, P1258

← 1 2 →