STUDY ON THE INDUCTION OF SPONTANEOUS TRANSMITTER RELEASE AT EARLY NERVE-MUSCLE CONTACTS IN XENOPUS CULTURES

被引：6

作者：

TABTI, N ^{[1
]}

POO, MM ^{[1
]}

机构：

[1] COLUMBIA UNIV, DEPT BIOL SCI, NEW YORK, NY 10027 USA

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

SYNAPTOGENESIS; SPONTANEOUS RELEASE; SPONTANEOUS SYNAPTIC CURRENT; ACETYLCHOLINE; INDUCTION; CALCIUM; CELL CULTURE;

D O I：

10.1016/0304-3940(94)90141-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

During synaptogenesis, spontaneous acetylcholine release is rapidly induced by the contact of the growing neurite with the myocyte. Using Xenopus nerve-muscle co-cultures, we investigated the role of Ca2+ in the presynaptic mechanisms mediating this induction process. We found that Ca2+ influx is not necessary to induce spontaneous release and that an increase in cytosolic Ca2+ is not sufficient to trigger this release in the absence of the target cell.

引用

页码：21 / 26

页数：6

共 24 条

[1]

ANDERSON DC, 1983, MOL PHARMACOL, V24, P48

[2] PROTON GRADIENT LINKAGE TO ACTIVE UPTAKE OF [H-3]-LABELED ACETYLCHOLINE BY TORPEDO ELECTRIC ORGAN SYNAPTIC VESICLES [J].