SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SEVERAL FLUORINATED ARTEMISININ DERIVATIVES

被引：51

作者：

PU, YM

TOROK, DS

ZIFFER, H

PAN, XQ

MESHNICK, SR

机构：

[1] NIDDK,CHEM PHYS LAB,BETHESDA,MD 20892

[2] UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 20期

关键词：

D O I：

10.1021/jm00020a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their in vitro antimalarial activities were all equal to or greater than the nonfluorinated analogs or precursors.

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页码：4120 / 4124

页数：5

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