LINCOMYCIN .8. 4'-ALKYL-L'-DEMETHYL-4'-DEPROPYLCLINDAMYCINS, POTENT ANTIBACTERIAL AND ANTIMALARIAL AGENTS

被引：28

作者：

MAGERLEIN, BJ

KAGAN, F

机构：

[1] Research Laboratories, Upjohn Company, Kalamazoo, Michigan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 05期

关键词：

D O I：

10.1021/jm00305a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of methyl 7(S)-chloro-7-deoxythioliueosaminide (4) is described and evidence favoring the 7(S) configuration for the 7-chloro substituent is presented. This compound was used in the preparation of 4′-alkyl-1′-demethyl-4′-depropylelindamycins shown to be potent antibacterial and antimalarial agents. © 1969, American Chemical Society. All rights reserved.

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页码：780 / +

页数：1

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