ANTICONVULSANT ACTIVITY OF MUSCIMOL AGAINST SEIZURES INDUCED BY IMPAIRMENT OF GABA-MEDIATED NEUROTRANSMISSION

被引：33

作者：

MATTHEWS, WD ^{[1
]}

MCCAFFERTY, GP ^{[1
]}

机构：

[1] SK&F LABS, DEPT BIOL RES, PHILADELPHIA, PA 19101 USA

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 11期

关键词：

bicuculline; isoniazid; pentylenetetrazole; picrotoxin; strychnine; tonic forelimb extension;

D O I：

10.1016/0028-3908(79)90086-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Muscimol is a potent in vivo agonist of GABA when tested iontophoretically and binds to GABA receptors in vitro. Muscimol effects on seizures induced by agents which impair GABA-mediated neurotransmission were studied in the rat. Muscimol delayed the onset of isoniazid- and picrotoxin-induced convulsions. The tonic forelimb extension component of bicuculine and metrazole seizures was abolished by muscimol. Inhibition of forelimb extension was chosen as an endpoint for comparison of clinically effective antiepileptics with muscimol. The order of potency was diazepam > muscimol .mchgt. phenobarbital > phenytoin. Muscimol had no effect on strychnine-induced convulsions. Muscimol apparently penetrates rat brain and specifically antagonizes seizures caused by GABA receptor blockade or depletion of brain GABA.

引用

页码：885 / 889

页数：5

共 24 条

[1]

AIRD RB, 1974, MANAGEMENT EPILEPSY

[2] DISTRIBUTION AND METABOLISM OF MUSCIMOL IN THE BRAIN AND OTHER TISSUES OF THE RAT [J].